Discovery of substituted 4-anilino-2-arylpyrimidines as a new series of apoptosis inducers using a cell-and caspase-based high throughput screening assay. 2. …

…, B Nguyen, C Crogan-Grundy, S Kasibhatla…

文献索引：Sirisoma, Nilantha; Pervin, Azra; Nguyen, Bao; Crogan-Grundy, Candace; Kasibhatla, Shailaja; Tseng, Ben; Drewe, John; Cai, Sui Xiong Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 8 p. 2305 - 2309

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被引用次数: 13

摘要

As a continuation of our efforts to discover and develop the apoptosis inducing 4-anilino-2-(2- pyridyl) pyrimidines as potential anticancer agents, we explored replacing the 2-pyridyl group by other aryl groups. SAR studies showed that the 2-pyridyl group can be replaced by a 3-pyridyl, 4-pyridyl and 2-pyrazinyl group, and that the SAR for the anilino group was similar to that of the 2-pyridyl series. However, replacement of the 2-pyridyl group by a ...