e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Discovery of substituted 4-anilino-2-arylpyrimidines as a new series of apoptosis inducers using a cell-and caspase-based high throughput screening assay. 2. …
As a continuation of our efforts to discover and develop the apoptosis inducing 4-anilino-2-(2- pyridyl) pyrimidines as potential anticancer agents, we explored replacing the 2-pyridyl group by other aryl groups. SAR studies showed that the 2-pyridyl group can be replaced by a 3-pyridyl, 4-pyridyl and 2-pyrazinyl group, and that the SAR for the anilino group was similar to that of the 2-pyridyl series. However, replacement of the 2-pyridyl group by a ...