Copper-catalysed N-arylation of pyrrole with aryl iodides under ligand-free conditions

…, F Wu, Y Liu, J Xie, B Dai, Z Zhou

文献索引：Liu, Lili; Wu, Fengtian; Liu, Yan; Xie, Jianwei; Dai, Bin; Zhou, Zhuoqiang Journal of Chemical Research, 2014 , vol. 38, # 3 p. 180 - 182

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被引用次数: 0

摘要

A simple, inexpensive and ligand-free copper-catalysed N-arylation of pyrrole with aryl iodides has been developed giving N-arylated products in moderate to excellent yields. The catalyst loading is relative low (5 mol%) and the catalyst system was stable in air. ... Keywords: copper, ligand-free, N-arylation, pyrrole, aryl iodides ... Pyrrole-containing heterocycles are ubiquitous in natural and well-represented among the desirable structures of modern medicinal ...