Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support

W Wang, L Li, C Jin, Y Niu, S Li, J Ma, L Li, Y Liu…

文献索引：Wang, Wenjun; Li, Lei; Jin, Chen; Niu, Yujie; Li, Sen; Ma, Ji; Li, Linfeng; Liu, Yu; Cai, Li; Zhao, Wei; Wang, Peng George Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5041 - 5044

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被引用次数: 4

摘要

The Letter describes a strategy for the enzymatic synthesis of glycans based on a pH- responsive water-soluble polymer. In neutral condition, the polymer is water-soluble and convenient for in-solution enzymatic synthesis, whereas in acidic condition (pH lower than 4.0), the polymer disconnects with the product and becomes insoluble, which can be easily removed. A 6-Sialyl lactose analogue was synthesized as a model reaction using this ...