Acidic pH??Responsive siRNA Conjugate for Reversible Carrier Stability and Accelerated Endosomal Escape with Reduced IFNα??Associated Immune Response

H Takemoto, K Miyata, S Hattori, T Ishii…

文献索引：Takemoto, Hiroyasu; Miyata, Kanjiro; Hattori, Shota; Ishii, Takehiko; Suma, Tomoya; Uchida, Satoshi; Nishiyama, Nobuhiro; Kataoka, Kazunori Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6218 - 6221 Angew. Chem., 2013 , vol. 125, # 24 p. 6338 - 6341,4

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被引用次数: 39

摘要

Small interfering RNA (siRNA) has garnered much interest as a potential drug because of its strong gene-silencing activity.[1] Toward the success in siRNA therapeutics, many strategies have been developed for efficient siRNA delivery into the cytosol of target cells.[2] Among them, siRNA conjugates have arisen as one of the promising strategies in siRNA delivery, as siRNA can be readily conjugated to a functional molecule to acquire the ability of “ ...