A facile synthesis of 5, 5??dideutero??4??dimethyl (phenyl) silyl??6??undecyl??tetrahydropyran??2??one as a deuterium labeled synthon for (−)??tetrahydrolipstatin and (+)?螃宁? …
…, R Chowdhury, S Mukhopadhyay…
文献索引：Wagh, Sandip J.; Chowdhury, Raghunath; Mukhopadhyay, Sulekha; Ghosh, Sunil K. Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 13 p. 649 - 654
Deuterium-labeled biologically active compounds are gaining importance because they can be utilized as tracers or surrogate compounds to understand the mechanism of action, absorption, distribution, metabolism, and excretion. Deuterated drug molecules (heavy drugs) become novel as well as popular because of better stability and bioavailability compared with their hydrogen analogs. Labeling of organic molecules with deuterium at ...
