Synthesis

Synthesis and application of N-methoxy-N-methyl-2-phenylsulfonylacetamide as a two-carbon homologating agent

N Satyamurthi, J Singh, IS Aidhen

文献索引：Satyamurthi; Singh, Jaimala; Aidhen, Indrapal Singh Synthesis, 2000 , # 3 p. 375 - 382

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被引用次数: 16

摘要

Abstract: With the well-known precedence that N-methoxy-N-methyl amides are excellent acyl cation and aldehyde equivalents, N-methoxy-N-methyl-2-phenylsulfonylacetamide (3), a new reagent, synthetically equivalent to QCH2CHO and QCH2COR was synthesised. The simplicity involved in the alkylation at the active methylene site in 3, followed by safe removal of the phenylsulfonyl group, makes 3 a versatile reagent for two-carbon ...