Synthesis and antibacterial activity of novel 3-O-carbamoyl derivatives of clarithromycin and 11, 12-cyclic carbonate azithromycin

L Zhang, L Song, Z Liu, H Li, Y Lu, Z Li, S Ma

文献索引：Zhang, Ling; Song, Linchen; Liu, Zhaopeng; Li, Hui; Lu, Yingdong; Li, Zerong; Ma, Shutao European Journal of Medicinal Chemistry, 2010 , vol. 45, # 3 p. 915 - 922

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被引用次数: 8

摘要

Two series of novel 3-O-carbamoyl derivatives of clarithromycin and 11, 12-cyclic carbonate azithromycin were designed, synthesized and evaluated for their in vitro antibacterial activities. Compounds 4j and 4k were the most potent activity against erythromycin- susceptible Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae, which were comparable to those of clarithromycin and azithromycin. ...