Tetrahedron

Zr (OBu t) 4 As an effective promoter for the Meerwein–Ponndorf–Verley alkynylation and cyanation of aldehydes: development of new asymmetric cyanohydrin …

T Ooi, T Miura, K Takaya, H Ichikawa, K Maruoka

文献索引：Ooi, Takashi; Miura, Tomoya; Takaya, Keisuke; Ichikawa, Hayato; Maruoka, Keiji Tetrahedron, 2001 , vol. 57, # 5 p. 867 - 873

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被引用次数: 67

摘要

Zr (OBut) 4 Can serve as an effective promoter for the Meerwein–Ponndorf–Verley alkynylation of aldehydes and also facilitate MPV type cyanide transfer to aldehyde carbonyls with commercially available acetone cyanohydrin under mild conditions. Based on this finding, a new procedure for asymmetric cyanohydrin synthesis has been developed employing (4R, 5R)-2, 2-dimethyl-α, α, α′, α′-tetraphenyl-1, 3-dioxolane-4, 5- ...