Tetrahedron

Zr (OBu t) 4 As an effective promoter for the Meerwein–Ponndorf–Verley alkynylation and cyanation of aldehydes: development of new asymmetric cyanohydrin …

T Ooi, T Miura, K Takaya, H Ichikawa, K Maruoka

Index: Ooi, Takashi; Miura, Tomoya; Takaya, Keisuke; Ichikawa, Hayato; Maruoka, Keiji Tetrahedron, 2001 , vol. 57, # 5 p. 867 - 873

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Citation Number: 67

Abstract

Zr (OBut) 4 Can serve as an effective promoter for the Meerwein–Ponndorf–Verley alkynylation of aldehydes and also facilitate MPV type cyanide transfer to aldehyde carbonyls with commercially available acetone cyanohydrin under mild conditions. Based on this finding, a new procedure for asymmetric cyanohydrin synthesis has been developed employing (4R, 5R)-2, 2-dimethyl-α, α, α′, α′-tetraphenyl-1, 3-dioxolane-4, 5- ...