Chemoenzymatic synthesis of the four diastereoisomers of 4-hydroxypipecolic acid from N-acetyl-(R, S)-allylglycine: chiral scaffolds for drug discovery
RC Lloyd, MEB Smith, D Brick, SJC Taylor…
文献索引：Organic Process Research and Development, , vol. 6, # 6 p. 762 - 766
... Organic Process Research & Development. ... The protected amino acids were subsequently esterified in thionyl chloride/methanol. Reaction of the ester (S)-8 in a solution of paraformaldehyde in formic acid using the procedure of Esch et al. ...
[Lloyd, Richard C.; Smith, Mark E. B.; Brick, Dean; Taylor, Stephen J. C.; Chaplin, David A.; McCague, Raymond Organic Process Research and Development, 2002 , vol. 6, # 6 p. 762 - 766]
![(R)-methyl 2-[N-(benzyloxycarbonyl)amino]-4-pentenoate结构式](https://image.chemsrc.com/caspic/219/127515-28-0.png)
