e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Chemoenzymatic synthesis of the four diastereoisomers of 4-hydroxypipecolic acid from N-acetyl-(R, S)-allylglycine: chiral scaffolds for drug discovery
RC Lloyd, MEB Smith, D Brick, SJC Taylor…
Index: Organic Process Research and Development, , vol. 6, # 6 p. 762 - 766
... Organic Process Research & Development. ... The protected amino acids were subsequently esterified in thionyl chloride/methanol. Reaction of the ester (S)-8 in a solution of paraformaldehyde in formic acid using the procedure of Esch et al. ...
[Lloyd, Richard C.; Smith, Mark E. B.; Brick, Dean; Taylor, Stephen J. C.; Chaplin, David A.; McCague, Raymond Organic Process Research and Development, 2002 , vol. 6, # 6 p. 762 - 766]
![(R)-methyl 2-[N-(benzyloxycarbonyl)amino]-4-pentenoate Structure](https://image.chemsrc.com/caspic/219/127515-28-0.png)
