Tetrahedron

Towards a versatile synthesis of kainoids I: Introduction of the C-3 and C-4 substituents

JE Baldwin, SJ Bamford, AM Fryer, MPW Rudolph…

文献索引：Baldwin, Jack E.; Bamford, Samantha J.; Fryer, Andrew M.; Rudolph, Martin P. W.; Wood, Mark E. Tetrahedron, 1997 , vol. 53, # 14 p. 5233 - 5254

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被引用次数: 37

摘要

The first stages in the synthesis of acromelic acid analogues from trans-4-hydroxy-L-proline are described. An enamine alkylation was used to stereospecifically introduce the C-3 substituent, Grignard addition to a ketone or Pd (0) catalysed cross-coupling procedures adding C-4 aryl substituents for further manipulation. A number of versatile intermediates were generated.