Tetrahedron

Niobium (V) chloride-catalyzed C–H insertion reactions of α-diazoesters: synthesis of β-keto esters

JS Yadav, BVS Reddy, B Eeshwaraiah, PN Reddy

文献索引：Yadav; Subba Reddy; Eeshwaraiah; Reddy Tetrahedron, 2005 , vol. 61, # 4 p. 875 - 878

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被引用次数: 53

摘要

Aldehydes react readily with ethyl diazoacetate in the presence of 5mol% of NbCl5 in dichloromethane to produce the corresponding β-keto esters in good yields with high selectivity. This method is very useful for the preparation of β-keto esters from both electron- rich as well as electron-deficient aromatic aldehydes under mild reaction conditions.