Synthesis and structure–activity relationship of a novel class of 15-membered macrolide antibiotics known as '11a-azalides'

T Sugimoto, T Tanikawa, K Suzuki…

文献索引：Sugimoto, Tomohiro; Tanikawa, Tetsuya; Suzuki, Keiko; Yamasaki, Yukiko Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5787 - 5801

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被引用次数: 7

摘要

Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections; however, the increasing prevalence of macrolide-resistant pathogens is a public health concern. Therefore, the development of new macrolide scaffolds with activities against resistant pathogens is urgently needed. An efficient method for reconstructing the erythromycin A macrolactone skeleton has been established. Based on this methodology, ...