Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure–activity relationship, structural biology, and cellular activity

P Innocenti, KMJ Cheung, S Solanki…

文献索引：Journal of Medicinal Chemistry, , vol. 55, # 7 p. 3228 - 3241

被引用次数: 34

摘要

... Journal of Medicinal Chemistry. ... Boronic esters 8 and 13 were formed using standard palladium chemistry(8) and subsequently coupled with 5-bromo-3-iodopyridin-2-amine under Suzuki conditions to afford bromopyridines 14.(10). ...

1666-28-0

2-羟基-4-溴苯甲酸

139102-34-4

4-溴-2-甲氧基苯甲酸甲酯

Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 ...

[Glennon, Richard A.; Raghupathi, Reva; Bartyzel, Piotr; Teitler, Milt; Leonhardt, Sigrun Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 734 - 740]

Design of potent and selective hybrid inhibitors of the mito...

[Innocenti, Paolo; Cheung, Kwai-Ming J.; Solanki, Savade; Mas-Droux, Corine; Rowan, Fiona; Yeoh, Sharon; Boxall, Kathy; Westlake, Maura; Pickard, Lisa; Hardy, Tara; Baxter, Joanne E.; Aherne, G. Wynne; Bayliss, Richard; Fry, Andrew M.; Hoelder, Swen Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3228 - 3241]

Discovery of a novel series of biphenyl benzoic acid derivat...

[Journal of Medicinal Chemistry, , vol. 51, # 6 p. 1925 - 1944]