Potential radiosensitizing agents. 6. 2-nitroimidazole nucleosides: Arabinofuranosyl and hexopyranosyl analogs

M Sakaguchi, CA Larroquette…

文献索引：Sakaguchi, Masakazu; Larroquette, Cynthia A.; Agrawal, Krishna C. Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 20 - 24

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被引用次数: 29

摘要

New 2-nitroimidazole nucleosides have been synthesized as radiosensitizers of hypoxic mammalian cells in an attempt to reduce the neurotoxicity and to increase the therapeutic efficacy of this class of agents. The trimethybilyl derivative of 2-nitroimidazole was condensed with 1-bromo-2, 3, 5-tri-O-benzoylarabinofuranose in the presence of mercuric cyanide to yield anomeric isomers of arabinofuranosides, which were separated by ...