Potential radiosensitizing agents. 6. 2-nitroimidazole nucleosides: Arabinofuranosyl and hexopyranosyl analogs

M Sakaguchi, CA Larroquette…

Index: Sakaguchi, Masakazu; Larroquette, Cynthia A.; Agrawal, Krishna C. Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 20 - 24

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Citation Number: 29

Abstract

New 2-nitroimidazole nucleosides have been synthesized as radiosensitizers of hypoxic mammalian cells in an attempt to reduce the neurotoxicity and to increase the therapeutic efficacy of this class of agents. The trimethybilyl derivative of 2-nitroimidazole was condensed with 1-bromo-2, 3, 5-tri-O-benzoylarabinofuranose in the presence of mercuric cyanide to yield anomeric isomers of arabinofuranosides, which were separated by ...