… of novel bifunctional organocatalysts: Highly enantioselective alcoholysis of meso cyclic anhydrides and its application for synthesis of the key intermediate of P2X 7 …
HJ Yang, FJ Xiong, J Li, FE Chen
文献索引：Yang, Hong-Jun; Xiong, Fang-Jun; Li, Jie; Chen, Fen-Er Chinese Chemical Letters, 2013 , vol. 24, # 7 p. 553 - 558
A family of novel squaramides/sulfamides based on 1, 2-alkamine was developed as chiral bifunctional catalysts to promote the asymmetric alcoholysis of meso cyclic anhydrides. The hemiesters were obtained in high yield with up to 93% ee. The usefulness of this methodology was demonstrated in the asymmetric synthesis of the key intermediate of P2X7 receptor antagonists.
