In the course of one of our antimalarial research projects, it became necessary to prepare 8- nitro-6, 7-dimethoxyquinoline, and the synthesis which quite naturally suggested itself was the application of the Skraup reaction to 3-nitro-4-aminoveratrole, just as 8-nitro-6- methoxyquinoline is obtained from 3-nitro-4-aniinoanisole in the manufacture of Plasmochin. The preparation of the requisite 3-nitro-4-aminoveratrole from vadlia has ...
[Collins, Terrence J.; Powell, Richard D.; Slebodnick, Carla; Uffelman, Erich S. Journal of the American Chemical Society, 1991 , vol. 113, # 22 p. 8419 - 8425]
