Bioorganic & medicinal chemistry letters

Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol

A Kamal, M Sandbhor, AA Shaik

文献索引：Kamal, Ahmed; Sandbhor, Mahendra; Ali Shaik, Ahmad Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4581 - 4583

全文：HTML全文

被引用次数: 30

摘要

Synthesis of both enantiomers of biologically active propranolol and sotalol has been achieved in high optical purity by one-pot reduction of 3 and 7 followed by in situ lipase resolution of the respective chlorohydrins. Pseudomonas cepacia lipase immobilized on ceramic particles (PS-C) provided the chlorohydrin and acetate, which on nucleophilic substitution with isopropyl amine afforded the target amino alcohols in high ...