Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of β-adrenergic receptor blockers

M Kapoor, N Anand, S Koul, SS Chimni, KS Manhas…

文献索引：Kapoor; Anand; Koul; Chimni; Manhas; Raina; Parshad; Taneja; Qazi Bioorganic Chemistry, 2003 , vol. 31, # 3 p. 259 - 269

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被引用次数: 20

摘要

(R)-and (S)-1-chloro-3-(1-naphthyloxy)-2-propanol are intermediates in the synthesis of β- adrenergic blocking agents and antihypertensive drugs such as propranolol and nadoxolol. Herein, improvement in the preparation of racemic 1-chloro-3-(1-naphthyloxy)-2-propanol generated from 1-naphthol and epichlorohydrin are reported. In addition, kinetic resolution studies have been conducted to obtain both (R) and (S)-1-chloro-3-(1-naphthyloxy)-2- ...