Journal of medicinal chemistry

Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation

P Singh, A Bhardwaj

文献索引：Singh, Palwinder; Mittal, Anu; Kaur, Satwinderjeet; Holzer, Wolfgang; Kumar, Subodh Organic and Biomolecular Chemistry, 2008 , vol. 6, # 15 p. 2706 - 2712

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被引用次数: 28

摘要

Rationally designed tetrahydropyrans (THPs) carrying one, two, or three aryl rings and other substituents were synthesized by the allylation of β-hydroxy ketones followed by iodocyclization. It has been observed that compounds with one aryl ring on THP are