Journal of medicinal chemistry

Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation

P Singh, A Bhardwaj

Index: Singh, Palwinder; Mittal, Anu; Kaur, Satwinderjeet; Holzer, Wolfgang; Kumar, Subodh Organic and Biomolecular Chemistry, 2008 , vol. 6, # 15 p. 2706 - 2712

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Citation Number: 28

Abstract

Rationally designed tetrahydropyrans (THPs) carrying one, two, or three aryl rings and other substituents were synthesized by the allylation of β-hydroxy ketones followed by iodocyclization. It has been observed that compounds with one aryl ring on THP are

 Related Synthetic Route
Benzaldehyde Structure

100-52-7

Benzaldehyde

4-Methoxybenzaldehyde Structure

123-11-5

4-Methoxybenzal...

~%

2-hydroxy-1-(4-methoxyphenyl)-2-phenyl-ethanone Structure

4254-17-5

2-hydroxy-1-(4-...

2-Hydroxy-1,2-bis(4-methoxyphenyl)ethanone Structure

119-52-8

2-Hydroxy-1,2-b...

Benzaldehyde Structure

100-52-7

Benzaldehyde

4-(Methylthio)benzaldehyde Structure

3446-89-7

4-(Methylthio)b...

~%

2-hydroxy-1-(4-(methylthio)phenyl)-2-phenylethan-1-one Structure

860699-91-8

2-hydroxy-1-(4-...

2-hydroxy-1,2-bis(4-methylsulfanylphenyl)ethanone Structure

42445-18-1

2-hydroxy-1,2-b...


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