Substituted N-{3-[(1, 1-dioxido-1, 2-benzothiazol-3-yl)(phenyl) amino] propyl} benzamide analogs as potent Kv1. 3 ion channel blockers. Part 2

…, S Dickerson, J Gobel, D Gillie, JP Condreay…

文献索引：Haffner, Curt D.; Thomson, Stephen A.; Guo, Yu; Petrov, Kimberly; Larkin, Andrew; Banker, Pierette; Schaaf, Gregory; Dickerson, Scott; Gobel, Jeff; Gillie, Dan; Condreay, J. Patrick; Poole, Chuck; Carpenter, Tiffany; Ulrich, John Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 6989 - 6992

全文：HTML全文

被引用次数: 6

摘要

We report the synthesis and in vitro activity of a series of novel substituted N-{3-[(1, 1-dioxido- 1, 2-benzothiazol-3-yl)(phenyl) amino] propyl} benzamide analogs. These analogs showed potent inhibitory activity against Kv1. 3. Several demonstrated similar potency to the known Kv1. 3 inhibitor PAP-1 when tested under the IonWorks patch clamp assay conditions. Two compounds 13i and 13rr were advanced further as potential tool compounds for in vivo ...