We report the synthesis and in vitro activity of a series of novel substituted N-{3-[(1, 1-dioxido- 1, 2-benzothiazol-3-yl)(phenyl) amino] propyl} benzamide analogs. These analogs showed potent inhibitory activity against Kv1. 3. Several demonstrated similar potency to the known Kv1. 3 inhibitor PAP-1 when tested under the IonWorks patch clamp assay conditions. Two compounds 13i and 13rr were advanced further as potential tool compounds for in vivo ...