A gold (I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor

…, D Kubutat, J Will, WS Sheldrick, P Jesse…

文献索引：Ott, Ingo; Qian, Xuhong; Xu, Yufang; Vlecken, Danielle H. W.; Marques, Ines J.; Kubutat, Dominic; Will, Joanna; Sheldrick, William S.; Jesse, Patrick; Prokop, Aram; Bagowski, Christoph P. Journal of Medicinal Chemistry, 2009 , vol. 52, # 3 p. 763 - 770

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被引用次数: 119

摘要

The novel luminescent gold (I) complex [N-(N′, N′-dimethylaminoethyl)-1, 8- naphthalimide-4-sulfide](triethylphosphine) gold (I) was prepared and investigated for its primary biological properties. Cell culture experiments revealed strong antiproliferative effects and induction of apoptosis via mitochondrial pathways. Biodistribution studies by fluorescence microscopy and atomic absorption spectroscopy showed the uptake into cell ...