A gold (I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor

…, D Kubutat, J Will, WS Sheldrick, P Jesse…

Index: Ott, Ingo; Qian, Xuhong; Xu, Yufang; Vlecken, Danielle H. W.; Marques, Ines J.; Kubutat, Dominic; Will, Joanna; Sheldrick, William S.; Jesse, Patrick; Prokop, Aram; Bagowski, Christoph P. Journal of Medicinal Chemistry, 2009 , vol. 52, # 3 p. 763 - 770

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Citation Number: 119

Abstract

The novel luminescent gold (I) complex [N-(N′, N′-dimethylaminoethyl)-1, 8- naphthalimide-4-sulfide](triethylphosphine) gold (I) was prepared and investigated for its primary biological properties. Cell culture experiments revealed strong antiproliferative effects and induction of apoptosis via mitochondrial pathways. Biodistribution studies by fluorescence microscopy and atomic absorption spectroscopy showed the uptake into cell ...