Polymethylene derivatives of pyrimidine nucleic bases bearing ω-functional groups

…, EA Uljanova, OD Zakharova, GA Nevinsky

文献索引：Makinsky; Kritzyn; Uljanova; Zakharova; Nevinsky Russian Journal of Bioorganic Chemistry, 2000 , vol. 26, # 10 p. 662 - 668

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被引用次数: 2

摘要

Abstract N 1-Acyclic derivatives of pyrimidine bases (uracil, thymine, and cytosine) with hydrophobic polymethylene chains containing various functional groups in an ω-position of the alkyl substituent were synthesized. Their physicochemical properties and inhibitory effect on the HIV reverse transcriptase and human DNA topoisomerase I were studied.