Abstract The carbocyclic analogs of thymidine (IXf), 1-β-ribofuranosylthymine (IXg), and 1-β- 3′-deoxyribofuranosyl-thymine (IXe) were synthesized by incorporating modifications into the Shaw method of synthesizing 2, 4-(1H, 3H) pyrimidinediones via acryloylureas. Simpler analogs of thymine nucleosides were also prepared by this method. The carbocyclic analog of thymidine displayed modest activity against Leukemia L1210 in vivo. It differs from a ...
![(+/-)-N-[[(1α,2β,4α)-2-hydroxy-4-(hydroxymethyl)cyclopentyl]aminocarbonyl]-3-methoxy-2-methyl-2-propenamide结构式](https://image.chemsrc.com/caspic/209/78795-21-8.png)
![2,4(1H,3H)-Pyrimidinedione,1-[(1R,2R,4S)-2-hydroxy-4-(hydroxymethyl)cyclopentyl]-5-methyl-, rel结构式](https://image.chemsrc.com/caspic/009/78795-26-3.png)
