A convergent strategy toward the synthesis of lateriflorone (5) is described. Our approach is based on biosynthetic considerations and draws on a sequence of prenylation, oxygenation and Claisen reactions for the construction of chromenequinone 6, and a tandem Claisen/Diels–Alder reaction cascade for the synthesis of caged tricycle 7. Union of fragments 6 and 7 led to the synthesis of seco-lateriflorone (49).
![6-溴-7-羟基-2,2-二甲基-4H-苯并[d][1,3]dioxin-4-酮结构式](https://image.chemsrc.com/caspic/334/531501-41-4.png)
