Synthesis and cytotoxicity of some d-mannose click conjugates with aminobenzoic acid derivatives

L Hradilová, M Poláková, B Dvořáková, M Hajdúch…

文献索引：Hradilova, Ludmila; Polakova, Monika; Dvorakova, Barbora; Hajduch, Marian; Petrus, Ladislav Carbohydrate Research, 2012 , vol. 361, p. 1 - 6

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被引用次数: 12

摘要

Two sets of new conjugates obtained from d-mannose derivatives and o-, m-, and p- substituted benzoic acid esters interconnected through a triazole ring were synthesized by Cu (I) catalyzed azide–alkyne cycloaddition. All synthesized compounds were tested for their in vitro cytotoxic activity against seven cancer cell lines with/without multidrug resistance phenotype as well as non-tumor MRC-5 and BJ fibroblasts. Butyl ester of 4- ...