Synthesis and aldose reductase inhibitory activity of N-(arylsulfonyl)-and N-(aroyl)-N-(arylmethyloxy) glycines

…, MS Belfiore, M Macchia, C Martini, S Nencetti…

文献索引：Balsamo, A.; Belfiore, M. S.; Macchia, M.; Martini, C.; Nencetti, S.; et al. European Journal of Medicinal Chemistry, 1994 , vol. 29, # 10 p. 787 - 794

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被引用次数: 16

摘要

Abstract Some N-(arylsulfonyl)-C and N-(aroyl)-N-(arylmethyloxy) glycines D were synthesised and tested as aldose reductase inhibitors (ARIs). They are structurally related to the previously described ARIs of type A and B, from which they differ owing to the presence of a spacer, an OCH 2 group, between the amino-acid nitrogen and the aromatic ring. The inhibitory activity was evaluated on the bovine lens aldose reductase enzyme. ...