The Journal of organic chemistry

Enantiospecific Total Synthesis of the Sarpagine Related Indole Alkaloids Talpinine and Talcarpine as Well as the Improved Total Synthesis of Alstonerine and …

P Yu, T Wang, J Li, JM Cook

文献索引：Yu, Peng; Wang, Tao; Li, Jin; Cook, James M. Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3173 - 3191

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被引用次数: 56

摘要

The enantiospecific total synthesis of talpinine 1 and talcarpine 2 has been accomplished from d-(+)-tryptophan in 13 steps (11 reaction vessels) in 10% and 9.5% overall yields, respectively. Moreover, this synthetic approach has been employed for the improved synthesis of alstonerine 3 and anhydromacrosalhine-methine 4 in 12% and 14% overall yield, respectively. A convenient synthetic route for the enantiospecific, stereospecific ...