Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents

…, AG Moglioni, M González, LM Finkielsztein

文献索引：Caputto, Maria E.; Fabian, Lucas E.; Benitez, Diego; Merlino, Alicia; Rios, Natalia; Cerecetto, Hugo; Moltrasio, Graciela Y.; Moglioni, Albertina G.; Gonzalez, Mercedes; Finkielsztein, Liliana M. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 22 p. 6818 - 6826

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被引用次数: 40

摘要

In the present work, we synthesized a series of thiosemicarbazones derived from 1- indanones with good anti-Trypanosoma cruzi activity. Most of them displayed remarkable trypanosomicidal activity. All the compounds showed nonspecific cytotoxicity on human erythrocytes. The ability of the new compounds to inhibit cruzipain, the major cysteine protease of T. cruzi, was also explored. Thiosemicarbazones 12 and 24 inhibited this ...