Preparation of 1-amino-4-methylpiperazine

PM Kushakova, AN Chernobroviy…

文献索引：Kushakova; Chernobroviy; Kuznetsov; Garabadgiu Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 12 p. 1546 - 1549

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被引用次数: 4

摘要

Abstract The selectivity of the formation of N-di (2-chloroethyl) methylamine in reactions with various chlorinating agents has been investigated and the optimum chlorinating agent has been found. 1-Amino-4-methylpiperazine has been obtained for the first time by the cyclization of N-di (2-chloroethyl) methylamine with aqueous hydrazine. A possible mechanism has been proposed for the cyclization reaction.