Synthesis of 4-methoxyphenoxyacetic and 3, 4, 5-trimethoxyphenoxyacetic acid amides and hydrazides as potential neurotropic and cardiovascular agents

V Valenta, J Holubek, E Svátek…

文献索引：Valenta, Vladimir; Holubek, Jiri; Svatek, Emil; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 12 p. 3013 - 3023

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被引用次数: 2

摘要

Abstract 4-Methoxyphenoxyacetyl chloride, 3, 4, 5-trimethoxyphenoxyacetic acid and its methyl ester were reacted with 2-phenylethylamine, 1-benzylpiperazine, 1-(2-phenylethyl) piperazine, 1-(1-phenyl-2-propyl) piperazine, isopropylhydrazine, 1-aminopiperidine, and 4- aminomorpholine and afforded the amides and hydrazides Iab-IVab and Vb-VIIIb. 1-Amino-4- methylpiperazine and 1-amino-4-phenylpiperazine were transformed to the hydrazones ...