TMP-zincate as highly chemoselective base for directed ortho metalation

…, M Shilai, M Uchiyama, T Sakamoto

文献索引：Kondo, Yoshinori; Shilai, Manabu; Uchiyama, Masanobu; Sakamoto, Takao Journal of the American Chemical Society, 1999 , vol. 121, # 14 p. 3539 - 3540

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被引用次数: 273

摘要

Since the pioneering work by Gilman and Wittig, 1 the directed ortho metalation reaction has been widely used as a powerful and efficient method for regioselective functionalization of aromatic compounds. 2 Various directing groups have been employed for facilitating the deprotonation of arenes, and various strong bases such as alkyllithiums or lithium dialkylamides have been employed. The ester group has been regarded as an important ...