Tetrahedron Letters

Reactivity and regioselectivity in Stille couplings of 3-substituted 2, 4-dichloropyridines

AD Khoje, LL Gundersen

文献索引：Khoje, Abhijit Datta; Gundersen, Lise-Lotte Tetrahedron Letters, 2011 , vol. 52, # 4 p. 523 - 525

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被引用次数: 6

摘要

The influence of substituents at C-3 of 2, 4-dichloropyridines on their reactivity and regioselectivity in Pd-catalyzed cross-couplings is studied. As a model reaction, the (Ph3P) 2PdCl2-catalyzed Stille coupling between 2-furyl (tributyl) tin and pyridines is chosen. Increased electron-withdrawing ability of a substituent at the pyridine 3-position improves the overall reactivity. Absolute selectivity for coupling at C-2 is achieved with an amino ...