A novel and highly efficient synthesis of gem-difluorocyclopropanes

…, V Kruger, O Bautista, JX Duan, AR Li, WR Dolbier…

文献索引：Tian, Feng; Kruger, Virginie; Bautista, Olivia; Duan, Jian-Xin; Li, An-Rong; Dolbier Jr., William R.; Chen, Qing-Yun Organic Letters, 2000 , vol. 2, # 4 p. 563 - 564

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被引用次数: 61

摘要

A new and highly versatile source of difluorocarbene is reported. Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) undergoes decomposition in the presence of catalytic fluoride to form difluorocarbene under conditions that allow its addition to relatively electron deficient alkenes in high yield. For example, unprecedented CF2: addition to n-butyl acrylate proceeded in 73% yield.