Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA): a new, highly efficient difluorocarbene reagent

…, AR Li, S Ait-Mohand, O Bautista, S Buathong…

文献索引：Dolbier Jr., William R.; Tian, Feng; Duan, Jian-Xin; Li, An-Rong; Ait-Mohand, Samia; Bautista, Olivia; Buathong, Saiwan; Baker, J. Marshall; Crawford, Jen; Anselme, Pauline; Cai, Xiao Hong; Modzelewska, Aneta; Koroniak, Henryk; Battiste, Merle A.; Chen, Qing-Yun Journal of Fluorine Chemistry, 2004 , vol. 125, # 3 p. 459 - 469

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被引用次数: 53

摘要

TFDA is readily prepared from the reaction of fluorosulfonyldifluoroacetic acid with trimethylsilyl chloride, and it is a very effective and efficient source of difluorocarbene for use in addition reactions to alkenes of a broad scope of reactivities. Acid-sensitive substrates may require an additional purification step involving treatment of the distilled TFDA with sufficient Et3N to remove the acid impurity. Other trialkylsilyl fluorosulfonyldifluoroacetates ...