1, 5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: Design, synthesis, and microbiological evaluation

…, GC Porretta, G Poce, A De Logu, R Meleddu…

文献索引：Biava, Mariangela; Porretta, Giulio C.; Poce, Giovanna; De Logu, Alessandro; Meleddu, Rita; De Rossi, Edda; Manetti, Fabrizio; Botta, Maurizio European Journal of Medicinal Chemistry, 2009 , vol. 44, # 11 p. 4734 - 4738

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被引用次数: 54

摘要

During the search of novel antitubercular drugs related to BM 212, new diarylpyrroles were designed and synthesized on the basis of a structure–activity relationship analysis of many pyrroles previously described by us. Among them, 1-(4-fluorophenyl)-2-ethyl-3- (thiomorpholin-4-yl) methyl-5-(4-methylphenyl)-1H-pyrrole (2b) proved to be particularly active, with a minimum inhibitory concentration (MIC, expressed as μg/mL) and a ...