Process development of 4-[N-methyl-N-(tetrahydropyran-4-yl) aminomethyl] aniline dihydrochloride: A key intermediate for TAK-779, a small-molecule nonpeptide …

H Hashimoto, T Ikemoto, T Itoh…

文献索引：Organic Process Research and Development, , vol. 6, # 1 p. 70 - 73

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被引用次数: 12

摘要

... Although extraction of the product into an organic solvent and washing with water is a well-known method to remove salts, this procedure ... To overcome this problem, we investigated the new process which does not require the neutralization procedure, allowing isolation of ...