Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-deoxy-β-D-ribofuranosyl)-and 9-(2, 3- …

…, A Holý, I Votruba, H Dvořáková

文献索引：Hocek, Michal; Holy, Antonin; Votruba, Ivan; Dvorakova, Hana Collection of Czechoslovak Chemical Communications, 2000 , vol. 65, # 11 p. 1683 - 1697

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被引用次数: 52

摘要

Abstract 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-6-(4-substituted phenyl) purines, 9-(5- deoxy-β-D-ribofuranosyl)-6-(4-substituted phenyl) purines and 9-(2, 3-dihydroxypropyl)-6-(4- substituted phenyl) purines were prepared by the Suzuki-Miyaura cross-coupling reactions of the corresponding protected 9-substituted 6-chloropurines with substituted phenylboronic acids followed by MeONa mediated deprotection. In contrast to the highly active 6- ...