Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine …
…, A Holý, I Votruba, H Dvoráková
文献索引：Hocek, Michal; Holy, Antonin; Votruba, Ivan; Dvorakova, Hana Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1817 - 1825
The Suzuki-Miyaura reaction of protected 6-chloropurine and 2-amino-6-chloropurine bases and nucleosides with substituted phenylboronic acids led to the corresponding protected 6- (substituted phenyl) purine derivatives 6-9. Their deprotection yielded a series of substituted 6-phenylpurine bases and nucleosides 10-13. Significant cytostatic activity (IC50 0.25-20 μmol/L) in CCRF-CEM, HeLa, and L1210 cell lines was found for several 6-(4-X- ...
