1, N6-Etheno-bridged adenines and adenosines. Alkyl substitution, fluorescence properties, and synthetic applications

PD Sattsangi, JR Barrio…

文献索引：Sattsangi, Prem D.; Barrio, Jorge R.; Leonard, Nelson J. Journal of the American Chemical Society, 1980 , vol. 102, # 2 p. 770 - 774

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被引用次数: 36

摘要

Abstract: It has been shown that the reaction of chloroacetaldehyde with adenosine at pH 4.5 and 37 OC that produces the fluorescent c-adenosine species will not develop interfering fluorescence with N6-alkyladenosines. The preferred site of methylation and benzylation of E-adenosine and c-adenine was established as N (9)(a) by acidic ring opening of the products to substituted aminobiimidazoles in which the two etheno protons ...