Structure–activity relationships for ketamine esters as short-acting anaesthetics

J Jose, SA Gamage, MG Harvey, LJ Voss…

文献索引：Jose, Jiney; Gamage, Swarna A.; Harvey, Martyn G.; Voss, Logan J.; Sleigh, James W.; Denny, William A. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5098 - 5106

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被引用次数: 4

摘要

Abstract A series of aliphatic esters of the non-opioid anaesthetic/analgesic ketamine were prepared and their properties as shorter-acting analogues of ketamine itself were explored in an infused rat model, measuring the time after infusion to recover from both the anaesthetic (righting reflex) and analgesic (response to stimulus) effects. The potency of the esters as sedatives was not significantly related to chain length, but Me, Et and i-Pr esters ...