The Journal of Organic Chemistry

Synthesis of ketamine metabolites I and II and some anomalous reactions of 6-bromoketamine

RF Parcell, JP Sanchez

文献索引：Parcell, Robert F.; Sanchez, Joseph P. Journal of Organic Chemistry, 1981 , vol. 46, # 25 p. 5055 - 5060

被引用次数: 17

摘要

Two metabolites of the drug ketamine, 2-(2-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride (l), la have been synthesized. They are the N-demethyl compound, metabolite I (131, and the N-demethyl-5, 6-dehydro analogue, metabolite I1 (15). Three bromo ketones derived from ketamine have also been synthesized and their relative configurations assigned. In addition, attempted dehydrohalogenation of axial 2-bromoketamine (2a) with ...

~85%

~57%

The CYP2B6* 6 allele significantly alters the N-demethylatio...

[Li, Yibai; Coller, Janet K.; Hutchinson, Mark R.; Klein, Kathrin; Zanger, Ulrich M.; Stanley, Nathan J.; Abell, Andrew D.; Somogyi, Andrew A. Drug Metabolism and Disposition, 2013 , vol. 41, # 6 p. 1264 - 1272]

Structure–activity relationships for ketamine esters as shor...

[Jose, Jiney; Gamage, Swarna A.; Harvey, Martyn G.; Voss, Logan J.; Sleigh, James W.; Denny, William A. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5098 - 5106]