Journal of the American Chemical Society

The Preparation of 5-Alkyl-5-(β-phenyl-and β-Vinyl-β-hydroxyethyl)-barbituric Acids Via the Corresponding α-Carbethoxy-γ-butyrolactones

GV Zyl, EE Tamelen

文献索引：Van Zyl; van Tamelen Journal of the American Chemical Society, 1950 , vol. 72, p. 1357

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被引用次数: 0

摘要

As early as 1899, Traube and Lehmann'condensed ethylene oxide and epichlorohydrin with malonic ester to yield a-carbethoxy-y-butyrolactone and a-carbethoxy-6-chloro-y- valerolactone, respectively. Since that time, the epoxide reaction with malonic ester has been extended by various workers. 2, 3, 4, b Because of inner transesterification, an a- carbethoxy-y-butyrolactone was always the only product that could be isolated, except in ...