N-Heteroarylmethyl-5-hydroxy-1, 2, 5, 6-tetrahydropyridine-3-carboxylic acid a novel scaffold for the design of uncompetitive α-glucosidase inhibitors

…, FR Stefani, S Biondi, G Ghiselli, M Panunzio

文献索引：Long, Sha; Stefani, Francesca Romana; Biondi, Stefano; Ghiselli, Giancarlo; Panunzio, Mauro Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5811 - 5822

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被引用次数: 6

摘要

Abstract The enzyme α-glucosidase has attracted interest owing to its involvement in the digestive process of carbohydrate, its role in intracellular glycoprotein trafficking, tumorigenesis and viral infection. In this study, several members of a new family of N- heteroarylmethyl substituted azasugars were synthesized and evaluated as α-glucosidase inhibitors. We systematically investigated the effect of different N-substituents as well as ...